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Newborn weight and its relationship to allergic diseases

 

 


 

How do I know if my baby has an allergy?

 

newborn


Allergies in newborns

 

A recent study showed that children who weigh more, at any gestational age, have a higher risk of developing food allergies, or childhood eczema, however, there was no increased risk of hay fever, and the paper, published in the Journal of Allergy and Clinical Immunology, found that the risk of food allergy Food increased by 44%, and eczema by 17%, for each kilogram of excess weight.

 

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The recent study and its results

 

Researchers looked at approximately 2.1 people with eczema, 70,000 with food allergies of various kinds, as well as 100,000 people with hay fever. All of these are allergic conditions. Eczema is also known as allergic dermatitis, and hay fever is like allergic rhinitis.

 

The data came from more than 15,000 studies, most of them in Europe, however, such allergies, in addition to asthma and anaphylaxis, are found in 30%, and 40% of the world's population.

 

 

They looked at whether a child's birth weight was associated with the risk of allergies in future childhood, even after correcting for weight, during the gestation period in which the child was born, and the researchers found a significant increase in risk, which was not found with children, who were Abnormally small at birth at gestational age.

 newborn 

Thus, it appears that these children have an immune system, which is preparing to resist allergic responses, but severe growth restriction is associated with an increased risk of developing other diseases, later in life, some of which are congenital and some are acquired.

What are the symptoms of allergy

Previous research studies on birth weight and allergic diseases

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The results are consistent with previous research, which shows an increased risk of emergency visits for asthma in newborns, who had a high birth weight, compared with those who had a normal weight range, and after 4.5 kg (the upper limit of normal birth weight), caused Each 100g weight gain, in a 10% increase, increased the risk of an asthma emergency visit. The older study also cited low income status, male gender, and indigenous ancestry as risk factors.

The various mechanisms that may increase the risk of developing asthma in children include deterioration of lung function, as a result of a decrease in airflow rate with expiration, in addition to an increase in the tendency of the small pulmonary airways to close when the pressure inside them decreases during expiration.

 newborn 

In addition, the action of the respiratory muscles is also weaker in these children. Obesity also increases the generalized inflammatory state, and may release molecules that cause inflammation of the airway. Fat cells may also cause activation of mast cells, which are directly related to spasm of smooth muscles in the airway. .

 

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implications and future directions

 

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 newborn weight 

Researcher Cathy Gutford says:

 

 You don't necessarily grow out of a childhood allergy, and sometimes you do, sometimes you don't. Things like an egg allergy will grow with a lot of kids, while a peanut allergy is more likely to persist, she says. They appear even in adults and may go undetected due to the lack of research in this field.

 

To increase or decrease the risk of developing allergies as a result, she says, mothers of older children must know how to change the conditions in their homes to protect their children from allergies. The answer lies not in ensuring growth-restricted children, but in understanding how this condition contributes to allergy protection.

Most of the studies reviewed were conducted in young children, and the researchers point to the need to conduct these investigations in older age groups, such as older children, adolescents and adults, to understand how and when low birth weight works, to improve a person's immunity, and to reduce susceptibility to infection. Sensitively, they also want to know whether this relationship fizzles out after a few years, or remains active over time.

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A food allergy is a hypersensitivity reaction, which means that before an allergic reaction occurs, to an allergen in a food, and a person needs to be previously exposed to or allergic to the food. Upon initial exposure, the allergen stimulates lymphocytes, (specialized white blood cells), to produce antibodies. Allergen-specific IgE antibodies.

 

This IgE is then released, attached to the surface of mast cells in various tissues of the body, and the next time a person eats that particular food, the allergen in the specific antibody, IgE, spills onto the surface of the mast cells, prompting the cells to release chemicals such as histamine.

These chemicals cause different food allergy symptoms, Dr. Stubler said, depending on the tissues in which they are released.

Risk of food allergy in premature infants

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Risk of food allergy in premature or low-birth-weight babies. Premature or low-birth-weight babies have increased intestinal permeability compared to full-term or normal-birth-weight babies.

 

To determine whether premature or low-birth-weight babies have an increased risk of food allergy compared to full-term or normal-birth-weight babies, the following was done:

A study was conducted on a Manitoba cohort born in 1995, using the Manitoba Health Services Insurance Plan (MHSIP) database. county health.

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A diagnosis of food allergy (ICD-9-CM code 693 in hospital/medical claims, or prescription injectable epinephrine, except the only diagnosis of toxin allergy) was reported until 2002.

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A total of 13,980 children were born in 1995 AD, and they still live in the province of Manitoba, and among these, 592 children (4.23%) were found to have food allergies, and epinephrine was prescribed to 316 children, or 2.26%, knowing that Neither gestational age, nor birth weight group had a statistically significant increased risk for food allergy.

 

conclusion

It was concluded from the foregoing in this study:

 

 Prematurity and low birth weight were not associated with a change in the risk of developing food allergies in infancy.

 

Clinical implications

 

The immaturity of the gastrointestinal tract, or immune response, does not appear to alter the risk of developing food allergies, raising the question whether early exposure to food antigens might protect premature infants by increasing immune tolerance to those antigens

 

 

With my best wishes

 



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